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What Is Thiafentanil?

Thiafentanil is a highly potent synthetic opioid analgesic and a fentanyl analog, structurally related to the widely known opioid fentanyl. It was originally developed for veterinary use—notably as a tranquilizer for large animals such as elephants, rhinos, and deer—rather than for human medicine.

Due to its extreme potency, tiny doses can be effective—and potentially lethal—in humans. In powdered form, thiafentanil appears as a white to off-white fine powder.

🧬 Chemical and Pharmacological Information

• Chemical Name: Thiafentanil oxalate

• IUPAC Name: N-phenyl-N-[1-(2-thienyl)ethyl-4-piperidyl]-propanamide

• Molecular Formula: C20H26N2O2S

• Drug Class: Synthetic opioid, fentanyl analog

• Potency: More potent than carfentanil, which itself is 10,000 times stronger than morphine

  Mechanism of Action

  Thiafentanil is a mu-opioid receptor agonist, meaning it binds to the same receptors in the brain and nervous system that natural opioids (like endorphins) and other opioids (like morphine) target.

  By activating these receptors, it causes:

  • Powerful analgesia (pain relief)

  • Profound sedation

  • Severe respiratory depression

  • Euphoria (in recreational contexts)

  • Potential loss of consciousness

    Intended Uses

    • Veterinary medicine only

    • Used as an immobilizing agent in large or wild animals, especially in wildlife conservation and research settings.

    • Not approved for human medical use under any regulatory framework.

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    ❌ Illicit Use and Concerns

    • Illicit manufacturing or misuse of thiafentanil is rare but extremely dangerous.

    • Some analogs may be sold online as “research chemicals” or mixed into street opioids without the user’s knowledge.

    • Given the incredibly small effective dose, unintentional overdoses are highly likely in such cases.

    • Thiafentanil is an ultra-potent synthetic opioid used only in veterinary medicine for sedating large animals. Due to its high potency, human exposure is extremely hazardous, even in minuscule amounts. Any handling or proximity to this substance outside of professional settings should be avoided. It serves as a stark example of the dangers posed by fentanyl analogs in the ongoing opioid crisis.

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