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SDB-006 is a synthetic cannabinoid, part of a growing class of man-made chemicals designed to mimic the psychoactive effects of THC (delta-9-tetrahydrocannabinol), the active ingredient in cannabis. Sold online and in some head shops as a “legal high,” SDB-006 has been linked to significant health risks, including toxicity, overdose, and severe adverse reactions.

This article provides an educational look at SDB-006—what it is, how it works, its effects, risks, and its status in the evolving legal landscape.

What is SDB-006?

• Chemical name: N-[(2S)-1-amino-3,3-dimethyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide

• Chemical class: Indazole-based synthetic cannabinoid

• Molecular formula: C22H30N4O2

• Molar mass: Approximately 386.50 g/mol

SDB-006 is structurally similar to other synthetic cannabinoids such as AB-FUBINACA and ADB-FUBINACA, which have appeared frequently in the “legal high” market since the early 2010s.

Buy SDB-006 Powder SDB-006 is a drug that acts as a potent agonist for the cannabinoid receptors, with an EC50 of 19 nM for human CB2 receptors, and 134 nM for human CB1 receptors. It was discovered during research into the related compound SDB-001 which had been sold illicitly as “2NE1”. SDB-006 metabolism has been described in literature.

Synthetic cannabinoids are the largest and most structurally diverse class of new psychoactive substances, with manufacturers often using isomerism to evade detection and circumvent legal restriction. The regioisomeric methoxy? and fluorine?substituted analogs of SDB?006 (N?benzyl?1?pentyl?1H?indole?3?carboxamide) were synthesized and could not be differentiated by gas chromatography–mass spectrometry (GC–MS), but were distinguishable by liquid chromatography–quadrupole time?of?flight–MS (LC–QTOF–MS). In a fluorescence?based plate reader membrane potential assay, SDB?006 acted as a potent agonist at human cannabinoid receptors (CB1 EC50 = 19 nM). All methoxy? and fluorine?substituted analogs showed reduced potency compared to SDB?006, although the 2?fluorinated analog (EC50 = 166 nM) was comparable to known synthetic cannabinoid RCS?4 (EC50 = 146 nM). Using biotelemetry in rats, SDB?006 and RCS?4 evoked comparable reduction in body temperature (~0.7°C at a dose of 10 mg/kg), suggesting lower potency than the recent synthetic cannabinoid AB?CHMINACA (>2°C, 3 mg/kg).

Technical Information
Formal Name: 1-pentyl-N-(phenylmethyl)-1H-indole-3-carboxamide
CAS Number: 695213-59-3
Molecular Formula: C21H24N2O
Formula Weight: 320.4
Purity: ?98%
Formulation: A crystalline solid
?max: 218, 291 nm
SMILES: CCCCCN1C=C(C(NCC2=CC=CC=C2)=O)C3=C1C=CC=C3
InChi CodeInChI=1S/C21H24N2O/c1-2-3-9-14-23-16-19(18-12-7-8-13-20(18)23)21(24)22-15-17-10-5-4-6-11-17/h4-8,10-13,16H,2-3,9,14-15H2,1H3,(H,22,24)
InChi Key: OLACYTSBFXCDOH-UHFFFAOYSA-N
Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ? 2 years
WARNING This product is not for human or veterinary use.