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Pentedrone also known as α‑methylaminovalerophenone—is a synthetic stimulant from the cathinone family, widely known in research circles as “penta crystal” or “crystal.” This compound is designed for scientific applications only and is available in high-purity crystalline form (≥98%), making it suitable for analytical and pharmacological use.

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Pentedrone functions as a norepinephrine–dopamine reuptake inhibitor (NDRI), mirroring the mechanism of medications like methylphenidate. Experimental studies show it dramatically increases locomotors activity and produces rewarding effects in animal models suggesting strong stimulant properties.

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Research shows that pentedrone exhibits high potency as an NDRI with limited impact on serotonin reuptake. In controlled animal tests, it has induced conditioned place preference, self-administration behaviors, and notable dopaminergic stimulation—underscoring both its efficacy and abuse potential. Toxicological assessments highlight its in vitro hepatotoxicity and lethal dosing thresholds.ResearchGate

Importantly, at least one fatal human case has involved pentedrone combined with another stimulant (α‑PVP), emphasizing the compound’s risk in poly-drug exposure.

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