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JWH-307 is a synthetic cannabinoid that belongs to a group of laboratory-created compounds designed to mimic the effects of THC, the psychoactive chemical found in cannabis. It was developed by chemist John W. Huffman, whose research into the endocannabinoid system led to the synthesis of hundreds of cannabinoids for scientific study.

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These compounds were not initially created for recreational use but became part of the unregulated drug market in the late 2000s and early 2010s. JWH-307, like many others in the JWH-series, was sold in products labeled as “herbal incense” or “legal highs,” often under names like “Spice” or “K2.”

Chemical Structure and Classification | Research chemical vendor Europe

JWH-307 is part of the naphthoylpyrrole family of synthetic cannabinoids. Its chemical name is (5-(2-fluorophenyl)-1-pentylpyrrol-3-yl)(naphthalen-1-yl)methanone.

Key chemical properties:

• Molecular Formula: C₂₆H₂₄FNO

• Molecular Weight: ~385.5 g/mol

• Structural Class: Naphthoylpyrrole

• Appearance: Typically a white to off-white powder in its raw form.

The structure features a naphthalene ring, a fluorinated phenyl group, and a pyrrole ring with a pentyl chain. These groups are responsible for binding the compound to cannabinoid receptors in the human body.

Mechanism of Action

JWH-307 functions as an agonist at cannabinoid receptors CB1 and CB2, which are part of the human endocannabinoid system. These receptors help regulate mood, memory, pain sensation, and appetite.

• CB1 receptors are found primarily in the brain and central nervous system.

• CB2 receptors are mostly found in peripheral organs, especially those involved in immune function.

JWH-307 has moderate selectivity for the CB2 receptor, meaning it binds slightly more readily to CB2 than CB1. Its binding affinity (measured by Ki values) is approximately:

• 7.7 nanomolar (nM) at CB1

• 3.3 nanomolar (nM) at CB2

These values indicate that JWH-307 is highly potent, binding strongly to both receptors at extremely low concentrations. This makes the compound pharmacologically active in microgram quantities.

Buy JWH-307 Crystal, it is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 7.7 nM at CB1 vs 3.3 nM at CB2. JWH-307 was detected as an ingredient in synthetic cannabis smoking blends in 2012, initially in Germany. JWH 307 5?-Isomer is an analogue of JWH 307 (J211800), a cannabimimetic that potently activates both the central cannabinoid (CB) receptor, CB1, and the peripheral CB2 receptor (Ki = 7.7 and 3.3 nM, respectively). The affinities of JWH-307 for both CB1 (Ki = 7.7 nM) and CB2 (Ki = 3.3 nM) are comparable to those of the traditional cannabinoid.

Technical Information
Formal Name: [5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-methanone
CAS Number: 914458-26-7
Molecular Formula: C26H24FNO
Formula Weight: 385.5
Purity: ?96%
Formulation: A crystalline solid
?max: 217, 250 nm
SMILES: O=C(C1=CN(CCCCC)C(C2=CC=CC=C2F)=C1)C3=C4C(C=CC=C4)=CC=C3
InChi CodeInChI=1S/C26H24FNO/c1-2-3-8-16-28-18-20(17-25(28)23-13-6-7-15-24(23)27)26(29)22-14-9-11-19-10-4-5-12-21(19)22/h4-7,9-15,17-18H,2-3,8,16H2,1H3
InChi Key: WYNZPDDTQGVCLZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ? 1 year

See also
JWH-147
WARNING This product is not for human or veterinary use.

JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11 nM at CB1 and 33 nM at CB2. Unlike many of the older JWH series compounds, this compound does not have a naphthalene ring, instead occupying this position with a 2?-methoxy-phenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands. Other 2?-substituted analogues such as the methyl, chloro and bromo compounds are also active and somewhat more potent.

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