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Synthetic cannabinoid FAB‑144 has garnered attention across European research institutions for its potent CB₁ receptor activity and structural similarity to XLR‑11. Whether you’re considering procurement for forensic analysis, medicinal chemistry, or academic study, it’s imperative to assess legal frameworks, supplier credibility, technical specifications, and safety protocols—especially within a European context.

What Is FAB‑144?

FAB‑144 is an indazole-based synthetic cannabinoid, functioning as an analog of XLR‑11 but with an indazole core instead of an indole one WikipediaGlpBio. Its molecular formula is C₂₀H₂₇FN₂O with a molecular weight of ~330.4 g/mol bertin-bioreagent.comNCATS Inxight Drugs. While it’s believed to act as a potent CB₁ receptor agonist, definitive physiological and toxicological profiles remain largely undocumented GlpBioResearchGateWikipedia.

Physicochemical Profile

• Structural identifiers include SMILES and InChI codes that map its precise structure. WikipediaNCATS Inxight Drugs

• Predicted properties:

  • Boiling point: ~436 °C

  • Density: ~1.13 g/cm³

  • Solubility: ~30 mg/mL in DMF, DMSO, ethanol; ~0.2 mg/mL in ethanol/PBS (1:4)

Safety & Handling

Due to its high potency and unknown toxicity, FAB‑144 must be handled with extreme caution. Key considerations include:

• Only use in licensed laboratories equipped for high-potency agents.

• Employ full PPE, including gloves, lab coat, fume hood, and eyewear.

• Use controlled micro-dosing procedures (e.g., dissolve in DMSO or methanol for accurate volume dosing), never weigh in open air.

• Avoid any human exposure, and strictly document all handling procedures.

• Research Applications

  FAB‑144 is marketed strictly for research or forensic use only, with manufacturers expressly prohibiting human consumption . Early pharmacological screening shows that FAB‑144 displays increased affinity for both CB₁ and CB₂ receptors, although data remains limited ResearchGatePMC. These profiles suggest potential value in receptor binding studies and molecular pharmacology—though the data is preliminary.

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• Summary

  FAB‑144 is a chemically complex synthetic cannabinoid with limited safety and pharmacological data. Its use is confined to research and forensic contexts. Researchers need to verify legal compliance, obtain proper high-purity sources, and implement stringent safety measures when handling this compound. If you’re interested in deeper pharmacology or legal details in specific regions, feel free to ask!