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5F-UR-144, also written as 5FUR-144, is a synthetic cannabinoid that has appeared in the designer drug market as part of a wave of “legal highs” sold under names like Spice, K2, or herbal incense. These substances are typically designed to mimic the effects of THC, the psychoactive ingredient in cannabis, while avoiding detection and regulation—at least initially.

5F-UR-144 is chemically similar to other synthetic cannabinoids like UR-144 and XLR-11, but features a fluorinated side chain, which increases potency and alters how the compound interacts with cannabinoid receptors. While it was initially developed for potential medical or scientific research, it has gained notoriety for its unpredictable effects and potential for serious harm.

What Is 5F-UR-144? | Purchase XLR-11

5F-UR-144 is a synthetic compound that acts as an agonist at cannabinoid receptors in the body, primarily CB1 and CB2 receptors. It is part of the tetramethylcyclopropyl synthetic cannabinoid family, which includes several structurally similar compounds.

• IUPAC Name: 1-(5-Fluoropentyl)-1H-indol-3-yl-methanone

• Chemical formula: C21H29FN2O

• Molecular weight: ~344.5 g/mol

• Common form: White or off-white powder, often dissolved and sprayed on herbal material

The name 5F-UR-144 indicates that it is a fluorinated analog of UR-144, with a fluorine atom attached to the terminal carbon of the pentyl side chain. This small change significantly affects its pharmacological properties, often increasing potency.

Chemical Structure and Classification

Key Features:

• Indole core: Common in many synthetic cannabinoids.

• 5-Fluoropentyl side chain: Enhances receptor binding.

• Tetramethylcyclopropyl group: A bulky, hydrophobic group that may affect metabolism and receptor affinity.

5F-UR-144 is categorized as:

• A synthetic cannabinoid receptor agonist (SCRA)

• Structurally similar to UR-144, XLR-11, and 5F-PB-22

• Often found in “herbal smoking blends” or e-liquids for vaporization

Buy 5FUR-144 Powder XLR-11 (5?-fluoro-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively.

It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-796,260 and A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other similar compounds, and appears to have not previously been made by Abbott Laboratories, despite falling within the claims of patent WO 2006/069196. XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3 mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135.

Detection
A forensic standard for this compound is available, and a representative mass spectrum has been posted on Forendex.

Side effects
XLR-11 has been linked to hospitalizations due to its use.

Recreational use
XLR-11 was instead first identified by laboratories in 2012 as an ingredient in synthetic cannabis smoking blends, and appears to be a novel compound invented specifically for grey-market recreational use.

Chemical and physical data
Formula: C21H28FNO