Buy 5fur-144 CRYSTAL

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Chemical Background

5F-UR-144 belongs to the UR-144 family of synthetic cannabinoids. Its chemical name includes “5F,” indicating the presence of a fluorine atom at the 5th position of the pentyl chain. The fluorination is common in synthetic cannabinoids because it can enhance the compound’s potency and influence its pharmacokinetics.

The molecular structure of 5F-UR-144 includes:

• An indole core, which is typical in many synthetic cannabinoids

• A pentyl chain modified with a fluorine atom (hence the “5F”)

• A carboxamide linker

This structure binds primarily to cannabinoid receptors CB1 and CB2 in the human body, mimicking natural cannabinoids like THC.

Buy 5fur-144 Crystal (XLR-11 or 5?-fluoro-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively.

It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-796,260 and A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other similar compounds, and appears to have not previously been made by Abbott Laboratories, despite falling within the claims of patent WO 2006/069196. XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3 mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135.

Chemical and physical data

Formula: C21H28FNO

Molar mass: 329.459 g·mol?1

Detection
A forensic standard for this compound is available, and a representative mass spectrum has been posted on Forendex

Side effects
XLR-11 has been linked to hospitalizations due to its use

Toxicity
XLR-11 has been linked to acute kidney injury in some users, along with AM-2201.

Legal Status
XLR-11 was banned in New Zealand by being added to the temporary class drug schedule, effective from 13 July 2012.

The U.S. Drug Enforcement Administration (DEA) made the synthetic cannabinoids UR-144, XLR11, and AKB48 Schedule I, illegal drugs under the Controlled Substances Act (CSA) for the next two years as of 16 May 2013.

It has also been banned in Florida as of December 11, 2012.

Arizona banned XLR-11 on 3 April 2013.

As of October 2015 XLR-11 is a controlled substance in China.

XLR-11 is banned in the Czech Republic

Mechanism of Action

5F-UR-144 acts as an agonist at cannabinoid receptors, mainly CB1 receptors found in the central nervous system and CB2 receptors located primarily in the immune system. By binding to these receptors, it activates intracellular signaling pathways similar to THC, the primary psychoactive component of cannabis.

CB1 receptor activation leads to altered neurotransmitter release, affecting mood, memory, pain perception, and motor control. CB2 receptor activation generally modulates inflammation and immune responses.