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What is 5F-ADB? | 5F-MDMB-PINACA supplier Europe

5F-ADB, also known as 5F-MDMB-PINACA, is a synthetic cannabinoid receptor agonist, developed to mimic the psychoactive effects of delta-9-tetrahydrocannabinol (THC). It is part of a group of chemicals known as new psychoactive substances (NPS) or “legal highs.” These substances are often sold under brand names like “Spice”, “K2”, or “herbal incense”, but they contain synthetic chemicals sprayed onto plant material.

5F-ADB is one of the most potent synthetic cannabinoids ever studied, with binding affinity to cannabinoid receptors (CB1 and CB2) far stronger than THC—meaning it acts more aggressively and with potentially dangerous outcomes.

Chemical Information | EU shipping for Research chemicals

• IUPAC Name: Methyl (2S)-2-{[1-(5-fluoropentyl)-1H-indazole-3-carbonyl]amino}-3,3-dimethylbutanoate

• Molecular Formula: C20H28FN3O3

• Chemical Class: Indazole-based synthetic cannabinoid

• Common Forms: Powder, liquid, sprayed on plant material

• Street Names: 5F-ADB, 5F-MDMB-PINACA, “Spice”, “K2”, “Herbal High”

How It Works | K2 spice powder COA

5F-ADB binds to CB1 receptors in the brain, the same receptors targeted by THC. However, it binds with much higher affinity, leading to more intense and unpredictable effects. The CB1 receptor is involved in regulating:

• Mood

• Memory

• Appetite

• Pain sensation

• Motor control

By overstimulating these receptors, 5F-ADB can cause severe toxicity and psychiatric symptoms.

Effects  | Buy cannabinoids for lab testing Europe

Acute Effects (can begin within minutes):

• Extreme euphoria or dysphoria

• Hallucinations

• Intense anxiety or panic attacks

• Paranoia

• Disorientation or confusion

• Agitation and aggression

• Nausea or vomiting

• Tachycardia (fast heart rate)

• Seizures

• Loss of consciousness

Severe and Fatal Reactions:

• Respiratory depression

• Kidney damage

• Cardiac arrest

• Coma

• Death

Even in small doses, 5F-ADB has caused fatal overdoses, especially when used unknowingly in mixed or mislabeled products.

Medical Emergencies 

Emergency departments have reported:

• Hundreds of hospitalizations

• Seizures and psychotic episodes

• Clusters of overdoses in prisons and homeless shelters

• Deaths due to multi-organ failure or cardiac arrest

In 2018, the CDC (Centers for Disease Control and Prevention) investigated dozens of deaths in the U.S. where 5F-ADB was a primary or contributing factor.