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PB-22, also known as QUPIC or SGT-21, is a synthetic cannabinoid that belongs to a class of designer drugs created to mimic the effects of natural cannabinoids like THC, the psychoactive compound in cannabis. It emerged in the early 2010s as part of the growing wave of synthetic cannabis products sold under names like “herbal incense” or “spice.” These products are often misleadingly labeled “not for human consumption,” but are widely used for their psychoactive effects.

BUY PB-22 POWDER (QUPIC or 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in synthetic cannabis products in Japan in 2013. The structure of PB-22 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear.

Chemical Structure and Properties | Research chemical supplier Europe

PB-22 is chemically known as 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester. Its molecular formula is C23H22N2O2, and it features a unique structure that sets it apart from earlier synthetic cannabinoids like JWH-018. Most synthetic cannabinoids use a ketone or amide group to link their components, but PB-22 is distinctive for using an ester linkage at the indole 3-position, and it includes a quinoline ring in place of a simpler aromatic group.

This structural difference may affect how PB-22 binds to the cannabinoid receptors in the human body and may also influence its metabolic pathway, potency, and toxicity.

QUPIC represents a structurally unique synthetic cannabinoid chemotype, since it contains an ester linker at the indole 3-position, rather than the precedented ketone of JWH-018 and its analogs, or the amide of APICA and its analogs. It has an EC50 of 5.1 nM for human CB1 receptors, and 37 nM for human CB2 receptors.

PB-22 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity. The magnitude and duration of hypothermia induced in rats by PB-22 was notably greater than JWH-018, AM-2201, UR-144, XLR-11, APICA, or STS-135, with a reduction of body temperature still observable six hours after dosing. One clinical toxicology study found PB-22 to be the cause of seizures in a human and his dog.

Pharmacology and Mechanism of Action | Legal research chemicals Europe

PB-22 is a potent full agonist at the CB1 and CB2 cannabinoid receptors found in the human endocannabinoid system. These receptors are responsible for the psychoactive and physiological effects associated with cannabinoids.

Compared to THC, which is a partial agonist, PB-22 is significantly more powerful. It binds more tightly to the CB1 receptor, which is primarily located in the brain and central nervous system, leading to stronger psychoactive effects. CB2 receptors, found mostly in immune tissues, are also affected, which can influence inflammation and immune response.

In animal studies, PB-22 has been shown to produce typical cannabinoid-like effects such as:

• Reduced movement

• Decreased body temperature (hypothermia)

• Lowered heart rate (bradycardia)

These effects were stronger and longer-lasting than those caused by many other synthetic cannabinoids.

Effects and Risks

PB-22 was initially developed for research but quickly found its way into recreational drug markets. Because it is often sprayed onto plant material and sold without quality control, the dosage can vary widely, making it especially dangerous.

Short-Term Effects

Users report a range of effects, including:

• Euphoria

• Altered perception

• Relaxation

• Anxiety or paranoia

• Visual and auditory hallucinations

• Nausea or vomiting

• Agitation or confusion

Serious Adverse Effects

There have been multiple reports of seizures, acute kidney injury, rapid heartbeat, psychosis, and loss of consciousness following PB-22 use. In some cases, the effects were so severe that emergency medical treatment was required. There have also been reports of fatal overdoses related to PB-22 and its analogs, particularly when mixed with other synthetic drugs or alcohol. BUY PB-22 POWDER Europe , PB-22 for sale Germany , Purchase PB-22 onlinePB-22 synthetic cannabinoid buy France , Order PB-22 powder Italy

The compound’s high potency and unpredictability make even small doses potentially harmful.

Metabolism and Detection

PB-22 is metabolized in the liver through oxidation and hydrolysis, producing a variety of byproducts. Some of these metabolites can still bind to cannabinoid receptors, which might extend the duration of the drug’s effects or contribute to toxicity.

Detecting PB-22 in biological samples like blood or urine requires specialized laboratory equipment and targeted drug testing methods. It typically isn’t picked up in standard drug screens unless those screens are designed to detect synthetic cannabinoids specifically.

Technical Information
Formal Name: 1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid
CAS Number: 1400742-41-7
Molecular Formula: C23H21FN2O2
Formula Weight: 376.4
Purity: ?99%
Formulation: A neat solid
SMILES: O=C(OC1=C(N=CC=C2)C2=CC=C1)C3=CN(CCCCCF)C4=C3C=CC=C4
InChi CodeInChI=1S/C23H21FN2O2/c24-13-4-1-5-15-26-16-19(18-10-2-3-11-20(18)26)23(27)28-21-12-6-8-17-9-7-14-25-22(17)21/h2-3,6-12,14,16H,1,4-5,13,15H2
InChi Key: MBOCMBFDYVSGLJ-UHFFFAOYSA-N
DEA Schedule: I
Legal status
As of 9 May 2014, PB-22 is no longer legal in New Zealand.

In January 2014, PB-22 was designated as a Schedule I controlled substance in the United States.

In Ohio, PB-22 is illegal.

Florida also has banned PB-22.

Since 13 December 2014 it is also illegal in Germany because of adding the substance to the BtMG Anlage II.

As of October 2015 PB-22 is a controlled substance in China

Detection
A forensic standard of PB-22 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.

Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ? 3 years