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UR-144 is a synthetic cannabinoid, a type of lab-created chemical that mimics the effects of THC, the primary psychoactive component in cannabis. First synthesized in the early 2010s by scientists researching the endocannabinoid system, UR-144 soon found its way into the “legal high” or “spice” market—sold in herbal smoking blends or as a pure powder for recreational use.

Although synthetic cannabinoids like UR-144 were initially marketed as legal alternatives to cannabis, they are not safe substitutes. UR-144 and its analogues have been associated with serious health risks, including seizures, psychosis, cardiovascular issues, and even death. This article provides a comprehensive, educational look at UR-144: what it is, how it works, and why it presents significant risks.

purchase UR-144 Powder (TMCP-018, KM-X1, MN-001, YX-17) may be a drug fancied by Abbott Laboratories, that acts as a selective full agonist of the peripheral cannabinoid receptor CB2, however with abundant lower affinity for the psychedelic CB1 receptor.Buy UR-144 Powder Europe , UR-144 Powder for sale Online Europe , where to Purchase UR-144 Germany , UR-144 Vendor in Europe , Order UR-144 Online Eu

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UR-144 has high affinity for the CB2 receptor with a Ki of 1.8 nM but 83x lower affinity for the CB1 receptor with a Ki of Associate in Nursingd fifty} nM. it absolutely was found to possess an EC50 of 421 nM for human CB1 receptors, and seventy two nM for human CB2 receptors. UR-144 produces arrhythmia and physiological state in rats at a dose of ten mg/kg, suggesting weak cannabinoid-like activity.

with chemicals it’s closely concerning alternative 2,2,3,3-tetramethylcyclopropyl artificial cannabinoids like A-796,260 and A-834,735 however with a special substitution on the 1-position of the indole core, in these compounds its 1-pentyl cluster is replaced with alkylheterocycles like 1-(2-morpholinoethyl) and 1-(tetrahydropyran-4-ylmethyl).

Chemical and physical information
Formula: C21H29NO

Molar mass: 311.461 g/mol g·mol?1

Dose
Inhalation (tentative because of an absence of information)

Range: 2.5 to twenty mg
the general public are exposed to the drug within the type of “blends” that contain variable levels of UR-144. It’s not informed use those products.

Timeline
Inhalation (tentative because of an absence of information)
Total: one – two hours
Onset: below ten minutes
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Mechanism of Action

UR-144 acts primarily as a full agonist at the CB2 receptor, and to a lesser extent at the CB1 receptor. These receptors are part of the body’s endocannabinoid system:

• CB1 receptors: Found mainly in the central nervous system (brain and spinal cord), responsible for psychoactive effects

• CB2 receptors: Found mostly in the immune system and peripheral tissues

Compared to THC, which is a partial agonist of CB1, UR-144 binds more strongly and activates the receptors more fully, which can lead to unpredictable and intense effects, even at low doses.