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5F-MMB-PICA is a synthetic cannabinoid, part of a class of designer drugs created to mimic the effects of THC, the psychoactive compound found in cannabis. These compounds interact with the body’s cannabinoid receptors but often with much higher potency and unpredictable effects. 5F-MMB-PICA has been found in some recreational synthetic cannabinoid products and is of interest both scientifically and from a public health perspective.

This overview covers the chemical nature, pharmacology, effects, risks, and legal considerations of 5F-MMB-PICA.

 synthetic cannabinoid also known as 5F-MMB-PICA, 5F-AMB-PICA, and I-AMB.

Chemical Structure and Nature

5F-MMB-PICA is part of the indole-3-carboxamide family of synthetic cannabinoids. Its full chemical name is methyl (2S)-2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethylbutanoate.

Key features of 5F-MMB-PICA’s structure include:

• Indole core: A bicyclic ring system typical in many synthetic cannabinoids.

• 5-fluoropentyl side chain: A five-carbon chain with a fluorine atom at the terminal position, which often increases binding affinity to cannabinoid receptors.

• MMB group: This refers to a methyl ester moiety attached to the carboxamide group.

This combination creates a molecule that can strongly bind to cannabinoid receptors in the body.

Mechanism of Action

5F-MMB-PICA acts as a full agonist at both CB1 and CB2 cannabinoid receptors.

• CB1 receptors, mainly found in the brain and central nervous system, mediate psychoactive effects such as altered mood, perception, and cognition.

• CB2 receptors, located mostly in peripheral tissues and immune cells, are involved in regulating inflammation and immune response.

Because 5F-MMB-PICA is a full agonist with high affinity, it can produce much stronger and more intense effects than THC, which is only a partial agonist.

Synonyms MDMB-2201 5-fluoro-MDMB-2201

CAS Number 1971007-88-1
Molecular Formula C21H29FN2O3
Formula Weight 376.5
Purity ?100%
Formulation A crystalline solid ?max 217, 290 nm
Control Status 5f mdmb 2201
5F-MDMB-PICA is a Schedule I controlled substance under the Federal Controlled Substances Act.

IllicitBuy 5f-mdmb-2201 online :
The National Forensic Laboratory Information System (NFLIS), a system that collects drug analysis information from state and local forensic laboratories, contain 340 reports for 5F-MDMB-PICA between 2016 and 2018.

Storage Information
Storage: -20°C
Shipping : Room Temperature in continental US; may vary elsewhere
Stability: ? 2 years
Pharmacology:
Data from preclinical studies show that 5F-MDMBPICA binds to and acts as an agonist at the CB1 receptor. There are no published studies on the safety of 5FMDMB-PICA for human use.

MMB-2201 is the indole core analogue of 5F-AMB. Synthetic cannabinoid compounds with an indole-3-carboxamide or indazole-3-carboxamide core bearing a N-1-methoxycarbonyl group with attached isopropyl or tert-butyl substituent, have proved to be much more dangerous than older synthetic cannabinoid compounds previously reported, and have been linked to many deaths in Russia, Japan, Europe and the United States.