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Buy 5F-AKB48 Powder (also known as 5F-AKB-48 or 5F-APINACA) is an indazole-based synthetic cannabinoid that has been sold online as a designer drug. Structurally it closely resembles cannabinoid compounds from patent WO 2003/035005 but with a 5-fluoropentyl chain on the indazole 1-position, and 5F-APINACA falls within the claims of this patent, as despite not being disclosed as an example, it is very similar to the corresponding pentanenitrile and 4-chlorobutyl compounds which are claimed as examples 3 and 4. In the United States, 5F-AKB48 is a Schedule I controlled substance.

5F-AKB48 is an Anlage II controlled drug in Germany since July 2013. As of October 2015, 5F-AKB48 is a controlled substance in China.

5F-AKB48 is banned in the Czech Republic.

Chemical Information

• Full Name: N-(1-Adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide

• Common Name(s): 5F-AKB48, 5F-APINACA

• Chemical Class: Synthetic cannabinoid (indazole-carboxamide)

• Molecular Formula: C23H31FN4O

• Structure Feature: Fluoropentyl chain on the indazole core, with an adamantyl group for increased receptor binding.

5F-AKB48 was first identified in South Korea. It is expected to be a potent agonist of the CB1 receptor and CB2 receptor. Its metabolism has been described in literature.

Chemical and physical data
Formula: C23H30FN3O

Molar mass: 383.5 g/mol g·mol?1

Pharmacology
5F-AKB48 acts as a full agonist with a binding affinity of 1.94 nM at CB1 and 0.266 nM at CB2 cannabinoid receptors.

How It Works (Mechanism of Action)

5F-AKB48 acts as a full agonist at the CB1 and CB2 receptors, which are part of the endocannabinoid system that regulates mood, memory, appetite, pain sensation, and motor control.

• CB1 receptors are located mainly in the brain and central nervous system.

• CB2 receptors are primarily found in the immune system and peripheral tissues.

Unlike THC (a partial agonist), 5F-AKB48 binds more strongly and activates these receptors more fully, making it far more potent and dangerous.