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1P-LSD (1-propionyl-lysergic acid diethylamide) is a semi-synthetic psychedelic and an analogue of LSD. It is most commonly distributed in blotter form—small squares of absorbent paper infused with a precise dose. 1P-LSD gained popularity in the early 2010s as a legal alternative to LSD in regions where LSD is prohibited, although its legal status has changed in many countries since.

What Are 1P-LSD Blotters?

Blotters are the most common method of distributing 1P-LSD. A blotter:

• Is a tiny square of paper (usually 6–7 mm wide)

• Is infused with a liquid solution of 1P-LSD

• Usually contains 100 µg per tab (though can vary)

Blotters are often printed with colorful designs or art and sold in sheets that are perforated into individual doses.

What is 1P-LSD?

• Full Name: 1-propionyl-lysergic acid diethylamide

• Chemical Formula: C₂₃H₂₉N₃O₂

• Class: Lysergamide psychedelic (structurally related to LSD)

• Potency: Similar to LSD, possibly slightly less potent

• Prodrug: 1P-LSD is believed to convert into LSD in the body after ingestion (via enzymatic cleavage of the propionyl group)

  How Does It Work?

  1P-LSD acts primarily as a partial agonist at 5-HT₂A receptors in the brain, similar to LSD. These receptors are part of the serotonin system and influence:

  • Perception

  • Cognition

  • Mood

  • Awareness of self and surroundings

  This leads to the classic psychedelic effects like visual distortions, time dilation, ego alteration, and synesthesia.

  when taken orally, LSD has an onset of action within 0.4 to 1.0 hours (range: 0.1–1.8 hours) and a duration of effect lasting 7 to 12 hours (range: 4–22 hours). It is commonly administered via tabs of blotter pape.LSD is extremely potent, with noticeable effects at doses as low as 20 micrograms and is sometimes taken in much smaller amounts for microdosing. Despite widespread use, no fatal human overdoses have been documented. LSD is mainly used recreationally or for spiritual purposes.LSD can cause mystical experiences.^[19][20] LSD exerts its effects primarily through high-affinity binding to several serotonin receptors, especially 5-HT_2A, and to a lesser extent dopaminergic and adrenergic receptors. LSD reduces oscillatory power in the brain’s default mode network and flattens brain hierarchy.At higher doses, it can induce visual and auditory hallucinations, ego dissolution, and anxiety LSD use can cause adverse psychological effects such as paranoia and delusions and may lead to persistent visual disturbances known as hallucinogen persisting perception disorder (HPPD).