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What Are Synthetic Cannabinoids?

Synthetic cannabinoids are man-made chemicals designed to mimic the effects of THC (tetrahydrocannabinol), the primary psychoactive compound in cannabis. Unlike natural cannabis, these synthetic substances are often far more potent and unpredictable, and they are frequently associated with serious health risks.

These substances are typically sprayed onto dried plant material and smoked or sold as liquids to be vaporized in e-cigarettes or other devices. Marketed under names like Spice, K2, Black Mamba, or Cloud 9, they are often labeled “not for human consumption” to evade regulation. Despite the misleading marketing, many people use them recreationally for their mind-altering effects.

How Synthetic Cannabinoids Work

Like THC, synthetic cannabinoids activate the CB1 and CB2 receptors in the brain and body’s endocannabinoid system. However, they often bind more strongly to these receptors, sometimes 100 times more strongly than natural THC. This can lead to much more intense and dangerous effects.