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What Are Stimulants?

Stimulants are a class of psychoactive substances that increase activity in the brain and central nervous system. They temporarily enhance alertness, energy, attention, and mood by speeding up mental and physical processes. Often referred to as “uppers,” stimulants contrast with depressants, which slow down brain activity.

Stimulants can be natural, such as caffeine or nicotine, or synthetic, like amphetamines and methylphenidate. Some stimulants are used medically to treat conditions like ADHD (Attention-Deficit/Hyperactivity Disorder), narcolepsy, and sometimes depression, while others are used recreationally or misused, leading to dependence and health issues.

How Stimulants Work (Mechanism of Action)

Stimulants mainly affect neurotransmitters—chemicals that transmit signals in the brain—especially:

• Dopamine: involved in pleasure, motivation, and reward.

• Norepinephrine: involved in alertness and focus.

• Serotonin: involved in mood and well-being (affected by some stimulants).

Stimulants either increase the release of these neurotransmitters or block their reuptake, keeping them active in the brain longer. This leads to heightened mental alertness, improved mood, and increased energy.