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Empathogens/entactogens are a class of psychoactive substances known for enhancing feelings of emotional openness, empathy, connectedness, and interpersonal closeness. The terms are often used interchangeably, though some researchers prefer entactogen (meaning “to touch within”) to emphasize internal emotional effects rather than just empathy toward others.

The most well-known compound in this category is MDMA (3,4-methylenedioxymethamphetamine), commonly called ecstasy or molly. Other substances sometimes described as empathogenic include MDA, MDEA, 2C-B, and certain substituted cathinones. While their chemical structures differ, their effects often share a similar emotional and social profile.

Pharmacologically, empathogens generally act by increasing the release of serotonin, dopamine, and norepinephrine in the brain, while also inhibiting their reuptake. The surge in serotonin is believed to underlie the characteristic mood elevation, empathy, and sense of bonding. Increased oxytocin release may also contribute to prosocial feelings.

People who use empathogens often describe enhanced communication, reduced fear or defensiveness, and a heightened sense of compassion. These qualities have made compounds like MDMA of interest in psychotherapy, especially for treating conditions such as post-traumatic stress disorder (PTSD), social anxiety, and relationship difficulties. Clinical trials with MDMA-assisted therapy have shown promising results, and the compound is moving toward potential approval as a therapeutic tool in controlled medical settings.

However, empathogens are not without risks. Recreational use, particularly at high or repeated doses, can lead to neurotoxicity, dehydration, overheating, cardiovascular strain, anxiety, or depression in the days following use (the so-called “comedown”). The illicit market also poses dangers of adulterated or misrepresented products, further increasing harm.

In summary, empathogens/entactogens are unique psychoactives that profoundly affect emotions and social connection. While they hold promise in clinical therapy, their recreational use carries significant health and safety risks.